Intracorporal Inflammation Sensors

On cardiovascular implants, the diagnosis of infection is often obstructed by difficult access to information at the implant surface, causing high morbidity and impairing efficient treatment. Precision medicine using sensors at the implant surface could thereby aid early diagnosis of localized infections. One of the main characteristics of infections is a localized increase in heat, which is due to localized bacterial growth in combination with metabolic heat of immune cells and increased blood perfusion. Our approach is to isolate the heat source in vitro in a microfluidic channel with control over the bacterial growth and flow rate. In addition, we leverage FEM simulation for design and application purposes. This research project is interdisciplinary bridging translational medicine, biology, microfabrication, microfluidics and sensor technology.

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